Comprehensive medical andrology pathways, advanced surgical sperm retrievals, and state-of-the-art laboratory micromanipulation protocols directed by Prof. (Dr.) Abha Majumdar.
Comprehensive tracking of semen parameters, specialized pharmacological therapies, and non-surgical restoration frameworks supervised by Prof. (Dr.) Abha Majumdar.
A major percentage of male factor reproductive challenges can be effectively resolved without requiring immediate laboratory processing. Targeted medical management focuses on restoring hormone balances, and correcting coital dynamics naturally.
Deployment of evidence-based oral pharmacological paths including selective estrogen receptor modulators (SERMs), precise metabolic regulators, and balanced gonadotropin lines. This optimizes the fundamental production cycle within testicular tissues to restore density and velocity profiles.
Management of Severe Sperm DNA Fragmentation Index (DFI):
Treating damaged or broken DNA inside the sperm that causes miscarriages.
Clinical Focus: OAT’S
Advanced medical management pathways target complex performance anxieties, erectile synchronization, and ejaculatory variances. This treatment targets to removes physical and mechanical execution barriers, securing optimal timed cycles. For this dysfunction our andrological team is referred to who specialise in helping these issues.
Clinical Focus:
Staging low grade varicocele via colour Doppler ultrasound monitoring prevents one from directly jumping to surgery. High-potency anti-inflammatory cells and specialized protective antioxidants are integrated to safely neutralize active Reactive Oxygen Species (ROS) and sperm DNA damage.
Our andrology team will examine you and will correctly advise you when surgery could help this condition. Doing a surgery where not required does not help the sperm count.
All diagnostic reviews, medical therapeutic timelines, and andrology evaluations are conducted under the professional direction of Prof. (Dr.) Abha Majumdar at the Centre of IVF & Human Reproduction, Sir Ganga Ram Hospital, New Delhi. Referrals are made to the appropriate andrological team.
State-of-the-art micromanipulation protocols, absolute male factor solutions, and micro-assisted surgical sperm retrievals directed by Prof. (Dr.) Abha Majumdar.
When physiological constraints create critical absolute barriers—such as complete absence of ejaculated sperms or very low counts—our embryology team under the able leadership of Dr. Gaurav Majumdar ‘Chief embryologist’, at Sir Ganga Ram Hospital IVF centre utilises advanced ferritization techniques for successful fertilization and embryo formation.
A micromanipulation technique executed under high-grade optical lens tracking system by which structurally ideal sperm is carefully isolated, immobilized, and injected directly into the central cytoplasm of the maternal oocyte.
Patient Meaning: Injecting one perfect sperm directly into an egg because it cannot swim or fertilize naturally.
Conventional fertilisation:
The ideal traditional way of fertilization is probably a better technique to use if the sperm count, motility and structure is normal. Here a number of sperms are placed directly in contact with one egg in the incubator in the IVF lab in a dish to promote self-fertilization. The best sperm which moves forward and fastest fertilises the egg.
Generally it is quoted that live birth rate using the method of conventional IVF for fertilization is superior to ICSI when we look at overall results.
Clinical Indications & Diagnostic Triggers (When do you need this?):
Advanced micro-surgical extraction tracks designed specifically for instances where no sperm cells are present in active ejaculated semen samples. These minimally invasive procedures are executed under precise local anaesthesia, safely retrieving viable sperms straight from reproductive storage zones of the testes.
Patient Meaning: Collecting sperm directly from the body when semen has zero sperm.
Surgical Selection Track (How sperm is collected):
Integrating highly advanced molecular screening parameters inside the laboratory setup to filter out hidden cellular defects before performing the final micromanipulation stage.
Methods and devices to choose only the healthiest sperm.
Advanced Lab Assays:
The ZyMōt Device: A microfluidic sperm separation tool used in IVF labs to isolate the healthiest, most motile sperm while avoiding centrifugation, which can cause DNA damage. It mimics the body’s natural selection process, yielding high-quality sperm for IUI, IVF, or ICSI treatments.
PICSI Assays: Places sperm in a dish coated with hyaluronan (a substance naturally found in the outer layer of eggs). The most mature, DNA-intact sperm bind to the dish and are then chosen for the injection.
Key Differences: ZyMōt vs. PICSI
| Feature | ZyMōt | PICSI |
|---|---|---|
| Selection Method | Natural swimming ability (motility) and minimal DNA fragmentation. | Ability to bind to hyaluronan (indicates maturity and DNA integrity). |
| Ideal Candidate | General male factor infertility, high DNA fragmentation, or optimizing standard sperm. | Patients with a history of failed fertilization, previous poor embryo quality, or recurrent miscarriages. |
| Procedure | Sperm “swim” through microscopic channels into a separate chamber. | Embryologist visually selects sperm that stick to the hyaluronic acid gel. |
All laboratory micromanipulations, clinical embryology tracks, and micro-surgical techniques respectively are executed under the absolute professional supervision of the clinical embryological chief Dr. Gaurav Majumdar and the clinical team under the supervision of Dr. Abha Majumdar at our Centre of IVF & Human Reproduction, Sir Ganga Ram Hospital, New Delhi.
